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KMID : 0371320070720020107
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Journal of the Korean Surgical Society
2007 Volume.72 No. 2 p.107 ~ p.112
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Safety and Efficacy of Postoperative Total Parenteral Nutrition (TPN) in Patients after Gastrectomy
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Lee In-Kyu
Kim Jong-Won
Cho Jae-Jin
Lee Hyuk-Joon
Choi Kook-Jin
Yang Han-Kwang
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Abstract
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Purpose: Total parenteral nutrition (TPN) has been widely used in malnourished, critically ill or surgical patients since the 1970’s. However, short-term application of TPN after elective gastrointestinal surgery has rarely been studied. The purpose of this study was to evaluate the safety and efficacy of postoperative TPN in patients after gastrectomy.
Methods: Forty seven patients who underwent elective gastrectomy from October 2005 to December 2005 were enrolled in this trial. Twenty two patients (TPN group) received multivitamin-containing TPN (Fulcaliqⓡ, Terumo, Japan) and 25 patients (control group) received the usual 10% dextrose solution for five days after surgery. Vital signs, body weight and nutritional support-related complications were evaluated on a daily basis. In addition, CBC, LFT, electrolyte, and trace elements were measured four times (preoperatively, POD1, POD 3 and POD 6).
Results: Nutritional support-related complications did not develop in the groups studied. Body weight and serum albumin levels were not different in comparisons between the two groups. However, in the TPN group, the total protein level on POD 6 had a tendency to be higher than in the control group. On POD 6, AST and ALT levels were significantly higher in the TPN group, but the total bilirubin and cholesterol levels were significantly higher in the control group.
Conclusion: Multivitamin-containing TPN appears to be safe and effective for patients, in the short term, after gastric surgery. (J Korean Surg Soc 2007;72:107-112)
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KEYWORD
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Total parenteral nutrition, Gastrectomy, Multivitamin, Clinical trial
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